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Alan R Katritzky's Profile

Homepage: http://www.ark.chem.ufl.edu/

Research Interests: Alan R. Katritzky

Born in London, U.K. Dual Citizen USA and UK; Web Homepage: http://www.ark.chem.ufl.edu/

Publications Selected from total of over 2,000 (Citation Analysis: h index 77 from 38,187 citations of 1,927 items)

1. Properties and Synthetic Utility of N-Substituted Benzotriazoles, Chem. Rev, 1998, 98, 409-548
2. Synthesis/bioassay of improved mosquito repellents predicted from structure, PNAS, 2008, 105, 7359-7364
3. Hydrogen Bonding Acidity and Basicity of Small Organic Molecules for the Prediction of Physical and ADMET Properties. Part 2. The Universal Solvation Equation, J. Chem. Inf. Mod., 2009, 49, 634-646.
4. Benzotriazole-Assisted Solid-Phase Assembly of Leu-Enkephalin, Amyloid β segment 34-42, and other “Difficult” Peptide Sequences, J. Org. Chem., 2009, 74, 2028-2032.
5. Quantitative Measures of Aromaticity for Mono-, Bi-, and Tricyclic Penta- and Hexa-atomic Heteroaromatic Ring Systems and Their Interrelationships, Chem.Rev., 2001, 101, 1421-1449.
6. Reactions in High-Temperature Aqueous Media, Chem.Rev., 2001, 101, 837-892.
7. Acylbenzotriazoles as Advantageous N-, C-, S-, and O-Acylating Agents, Synlett, 2005, 11, 1656-1665.

Distinctions FRS, 1980

Foreign Membership of Academies: Polish Academy Sci; Catalonian Academy (Spain); Russian Academy Sci Siberian Sect; Indian Nat Academy Sci; Roy Aust Institute;Slovenian Academy; European Academy of Arts and Sciences; International Academy of Mathematical Chemistry.

Civil Decoration: Cavalieri Ufficiale Order “Al Merito della Republica Italiana.”

Honorary Fellowships: St Catherine’s College (Oxford, UK); Italian Chem Soc; Polish Chem Soc; Egyptian Soc Heterocyclic Chem.

Honorary Doctorates from 14 Universities in: Belgium (Gent), England (East Anglia), Estonia (Tartu), France (Toulouse), Germany (Jena), India (Bundelkhand), Poland (Poznan, Gdansk, Wrotzlaw), Romania (Bucharest, Timisoara), Russia (St. Petersburg, Rostov), Spain (Madrid, U Nat)

Medals, Prizes, and Awards from: Roy Soc of Chem (Robinson award; Tilden and Heterocyclic medals); Am Chem Soc (Cope Senior Scholar and Florida Award); Tartu Univ (360 year comm.); Exxon Corp (Golden Tiger Award); U Thessaloniki (Aristotle medal); Internat Soc Het. Chem (Prize); Latvian Acad Sci (Hillier medal); Czech Acad Sci (Heyrovsky Medal); Chinese Univs (Hon Prof of Beijing Inst Tech and Xian Mod U); Germany (Senior Humboldt); Egypt (President Ibin Sina Conf); Japan (Kametani Prize); Am Assoc Adv Sci (Fellow); Polish Chem Soc (Curie medal); Sci Partnership Found of Moscow (Gold medal, Globe award); Indian Chem Soc (Lifetime Achievement Award).

Alan R Katritzky's Projects

Physical Science - Synthesis of Peptide Conjugates
Principal Investigator: Alan R Katritzky

α-Amino acids and their derivatives are central to the chemistry and biology of peptides and proteins. They are also versatile synthetic building blocks for pharmaceutical applications, precursors for the generation of molecular diversity. Attaching amino acid and peptide groups to heterocyclic moieties can increases pharmaceutical value. Our aim is to synthesize different nitrogen containg heterocycles with attached amino acids, using acylbenzotriazoles as a coupling reagent. Applicant will help in synthesizing the compounds with their characterizations by using NMR, Mass spectroscopy, elemental analysis.α-Amino acids and their derivatives are central to the chemistry and biology of peptides and proteins. They are also versatile synthetic building blocks for pharmaceutical applications, precursors for the generation of molecular diversity. Attaching amino acid and peptide groups to heterocyclic moieties can increases pharmaceutical value. Our aim is to synthesize different nitrogen containg heterocycles with attached amino acids, using acylbenzotriazoles as a coupling reagent. Applicant will help in synthesizing the compounds with their characterizations by using NMR, Mass spectroscopy, elemental analysis.

Requirements: Completion of Organic Chemistry 2210, 2211, 2211L

Time Commitment:

Independent Study: Available
Work Study: Not Available
Salary: Not Available
Volunteer: Available
Physical Science - Novel Flourescent Probes
Principal Investigator: Alan R Katritzky

Fluorescence spectroscopy is a valuable tool for biochemical research on ions, biosensors, and processes such as protein folding, protein-protein interactions, and phosphorylation. While many fluorescence applications rely on the use of intrinsic fluorophores, the development of new extrinsic fluorophores remains an essential element for the design of new fluorescent probes. Organic fluorophores based on a naphthalene nucleus, usually with an amino substituent, have aroused the interest of photochemists and photobiologists because of their sensitivity to solvent effects. Substantial changes in the fluorescence spectrum, quantum yield, and lifetime are often observed with solvent changes or as a result of binding to a substrate. In this project, a new environmentally sensitive chlorine-substituted napthalimide-based fluorophore will be synthesized and then will be coupled with free and Fmoc-protected amino acids. The products will be characterized and their fluorescence properties in different solvents will be studied. SO

Requirements: Completion of Organic Chemistry 2210, 2211, 2211L

Time Commitment:

Independent Study: Not Available
Work Study: Not Available
Salary: Not Available
Volunteer: Available
Physical Science - Depsides and Depsipeptides
Principal Investigator: Alan R Katritzky

The project will use benzotriazole methodology) to synthesis depsides and depsipeptides. Naturally occurring depsides and depsipeptides are analogs to peptides. Depsides are composed of α-hydroxy acids linked by ester bonds; depsipeptides are composed of both hydroxy and amino acids linked by ester and amide bonds. Many of them exhibit significant biological activities such as antimicrobial, antifungal, anti-inflammatory and moreover that they have applicable therapeutic properties including anticancer and anti-HIV. Applicant will help with synthesis and purification of these depsides and depsipeptides. Purification of compounds will be done using recrystallisation, column chromatography or distillation techniques. Applicant will also help with characterization of these compounds using nuclear magnetic resonance spectroscopy, mass spectroscopy, elemental analysis and high pressure liquid chromatography.

Requirements: Completion of Organic Chemistry 2210, 2211, 2211L

Time Commitment:

Independent Study: Not Available
Work Study: Not Available
Salary: Not Available
Volunteer: Available
Physical Science - Aminoxy Peptides
Principal Investigator: Alan R Katritzky

-Aminoxy peptides have received considerable interest as a novel foldamers. Aminoxy peptides attract much attention because of their unusual conformations and interesting bioactivities. Peptides containing -aminoxy acids are good receptors for anions because of the acidity of their aminoxy amide protons. Solid-phase peptide synthesis (SPPS) has become a major technique for rapid synthesis of potentially bioactive peptides. The increased efficiency of SPPS has resulted in its near-exclusive use for the preparation of peptides which in turn led to better coupling reagents, better yields and shorter coupling times. Applicant will help with synthesis and purification of these aminoxy peptides using microwave assisted solid-phase peptide synthesis. Applicant will also help with characterization of these compounds using nuclear magnetic resonance spectroscopy, mass spectroscopy, elemental analysis and high pressure liquid chromatography.

Requirements: Completion of Organic Chemistry 2210, 2211, 2211L

Time Commitment:

Independent Study: Not Available
Work Study: Not Available
Salary: Not Available
Volunteer: Available
Physical Science - Small Depsipeptides
Principal Investigator: Alan R Katritzky

The goal of our project is to synthesize small depsipeptides. The synthesis of these molecules (e.g.: L-Lys-D-Ala-D-Lac) is relevant to problems associated with the resistance of bacteria to the glycopeptides antibiotic vancomycin, which is considered to be the last resort for the treatment of infections caused by Gram-positive bacteria. The simple replacement of an amide NH-group with an ester-oxygen results in the replacement of a stabilizing hydrogen bond with a destabilizing lone pair-lone pair repulsion within the vancomycin-ligand complex. Students will be trained to work in organic laboratory to synthesize (reactions under anhydrous and non-anhydrous atmosphere, reactions at room temperature, under reflux or at low temperature), purify (TLC and chromatography column, also the technique for crystallization) and analyze (1H- and 13C-NMR, CHN) small depsipeptide conjugates.

Requirements: Completion of Organic Chemistry 2210, 2211, 2211L

Time Commitment:

Independent Study: Not Available
Work Study: Not Available
Salary: Not Available
Volunteer: Available